Copyright © Th+R Slegtenhorst 1994-2009

Human Chorionic Gonadotropin, hCG Pictures
update: 22Mar 06   « page_foot 
 GLASGOW University,   1994.
 Joseph Black Chair of Protein Crystallography

Weight Loss Methods
Compared + Explained
rconsult
The structure of hCG was first determined in Glasgow at 3.0Ang resolution. Each molecule
has two beta-hairpin loops on one side of a central cystine knot and a long loop on the other.
REFERENCES
 95 ) Structural and molecular studies of human chorionic gonadotropin
 96 ) Molecular Structure of Gonadotropins
 97 ) Glycoprotein hormones, Gonadotropin sequences;  A discussion of the alpha subunit (generic) and the beta subunits (specific)

hCG Human Chorionic Gonadotropin is a glycoprotein hormone

Surface diagram of hCG. The alpha subunit is coloured in blue, the beta subunits in green. The carbohydrate structure is shown in spheres and coloured according to atom type.

Surface potential of hCG. Large positively charged (blue) region of the molecule (mainly beta subunit residues, some from the alpha subunit 'long loop'). The charge, located predominantly on one face of the molecule which, is involved in receptor binding.

Ribbon of both subunits coloured blue for alpha, green for beta. The disulphide bridges are shown in yellow. The molecule is covered in a dot surface coloured by charge.
 
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Glycoprotein hormone alpha & beta chains

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